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Fig. 5 | BMC Microbiology

Fig. 5

From: Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions

Fig. 5

Antimicrobial activity of hybrid peptide AvBD-12/6. Bacteria (105 CFU/ml) were incubated with peptides at various concentrations, ranging from 2 to 128 μg/ml, at 37 °C for 2 h. Antimicrobial activity was presented as percent of killing compared to non-AvBD treated control. Antimicrobial activity of analogue AvBD-12/6 against E. coli (a), P. aeruginosa (b), S. Typhimurium (c) and S. aureus (d). Wild-type AvBD-6 and AvBD-12 were included as controls. Data are means ± SD (n = 3). Statistical analysis was performed using the one-way analysis of variance (ANOVA) followed by Duncan’s test for multiple comparisons using software SPSS version 19.0 (IBM Corp., Armonk, NY). Asterisks indicate statistically significant difference between the hybrid analogue and AvBD-12 at the same concentrations (*p < 0.05). Solid line: average killing percent of 32 μg/ml of wild-type AvBD-12. Dash line: average killing percent of 4 μg/ml of wild-type AvBD-12

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