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Fig. 4 | BMC Microbiology

Fig. 4

From: Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions

Fig. 4

Antimicrobial activity of group 2 analogues. Bacteria (105 CFU/ml) were incubated with peptides at various concentrations, ranging from 2 to 128 μg/ml, at 37 °C for 2 h. Antimicrobial activity was presented as percent of killing compared to non-AvBD treated control. Antimicrobial activity of analogues AvBD-12A4 to A6 against E. coli (a), P. aeruginosa (b), S. Typhimurium (c) and S. aureus (d). Wild-type AvBD-6 and AvBD-12 were included as controls. Data are means ± SD (n = 3). Statistical analysis was performed using the one-way analysis of variance (ANOVA) followed by Duncan’s test for multiple comparisons using software SPSS version 19.0 (IBM Corp., Armonk, NY). Asterisks indicate statistically significant difference between analogues and AvBD-12 at the same concentrations (*p < 0.05). Solid line: average killing percent of 32 μg/ml of wild-type AvBD-12. Dash line: average killing percent of 4 μg/ml of wild-type AvBD-12

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