Table 1 Patient demographic information and phenotypic and genotypic characteristics of four invasive capsule null Neisseria meningitidis isolates identified through national laboratory-based surveillance in South Africa, 2003–2013
From: Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa
Characteristic | ||||
Patient | 1 | 2 | 3 (Episode 1)a | 3 (Episode 2)a |
 Gender | Male | Male | Male | Male |
 Age category (years) | 45–64 | 15–24 | 5–9 | 5–9 |
 HIV status | Negative | Unknown | Negative | Negative |
 Antiretroviral use | Not applicable | Unknown | Not applicable | Not applicable |
 Underlying disease | Diabetes mellitus, COPD | Unknown | C6 deficiency | C6 deficiency |
 Year of disease presentation | 2006 | 2010 | 2011 | 2012 |
 Province | Western Cape | Gauteng | Free State | Free State |
 Patient outcome | Recovered | Recovered | Recovered | Recovered |
 Specimen type | Pleural aspirate | CSF | CSF | Blood |
Isolate | ||||
Minimum Inhibitory Concentrations (μg/ml) | ||||
 Penicillin G | 0.032 (S) | 0.064 (S) | 0.064 (S) | 0.047 (S) |
 Ceftriaxone | ≤0.002 (S) | ≤0.002 (S) | ≤0.002 (S) | ≤0.002 (S) |
 Trimethoprim-sulfamethoxazole | 8 (R) | 12 (R) | 3 (R) | 3.8 (R) |
 Chloramphenicol | 0.75 (S) | 1 (S) | 1 (S) | 0.38 (S) |
 Rifampicin | 0.008 (S) | 0.032 (S) | 0.064 (S) | 0.032 (S) |
 Ciprofloxacin | 0.008 (S) | 0.008 (S) | 0.006 (S) | 0.006 (S) |
Molecular characterization | ||||
  cnl allele (NEIS2743) | 12 | 2 | 2 | 2 |
 Strain designation | NG: P1.7-2,30: F1-2: ST-53 (cc53) | NG: P1.18-11, 42-2: FΔ: ST-192 (cc192) | NG: P1.18-11, 42-2: FΔ: ST-192 (cc192) | NG: P1.18-11, 42-2: FΔ: ST-192 (cc192) |
Genome information | ||||
 Approx genome size (bp) | 2,104,685 | 2,040,849 | 1,995,940 | 2,003,633 |
 No. contigs | 119 | 111 | 447 | 489 |
  Neisseria PubMLST.org identification number | 29312 | 29306 | 41961 | 41860 |