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Table 1 Patient demographic information and phenotypic and genotypic characteristics of four invasive capsule null Neisseria meningitidis isolates identified through national laboratory-based surveillance in South Africa, 2003–2013

From: Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa

Characteristic
Patient 1 2 3 (Episode 1)a 3 (Episode 2)a
 Gender Male Male Male Male
 Age category (years) 45–64 15–24 5–9 5–9
 HIV status Negative Unknown Negative Negative
 Antiretroviral use Not applicable Unknown Not applicable Not applicable
 Underlying disease Diabetes mellitus, COPD Unknown C6 deficiency C6 deficiency
 Year of disease presentation 2006 2010 2011 2012
 Province Western Cape Gauteng Free State Free State
 Patient outcome Recovered Recovered Recovered Recovered
 Specimen type Pleural aspirate CSF CSF Blood
Isolate
Minimum Inhibitory Concentrations (μg/ml)
 Penicillin G 0.032 (S) 0.064 (S) 0.064 (S) 0.047 (S)
 Ceftriaxone ≤0.002 (S) ≤0.002 (S) ≤0.002 (S) ≤0.002 (S)
 Trimethoprim-sulfamethoxazole 8 (R) 12 (R) 3 (R) 3.8 (R)
 Chloramphenicol 0.75 (S) 1 (S) 1 (S) 0.38 (S)
 Rifampicin 0.008 (S) 0.032 (S) 0.064 (S) 0.032 (S)
 Ciprofloxacin 0.008 (S) 0.008 (S) 0.006 (S) 0.006 (S)
Molecular characterization
cnl allele (NEIS2743) 12 2 2 2
 Strain designation NG: P1.7-2,30: F1-2: ST-53 (cc53) NG: P1.18-11, 42-2: FΔ: ST-192 (cc192) NG: P1.18-11, 42-2: FΔ: ST-192 (cc192) NG: P1.18-11, 42-2: FΔ: ST-192 (cc192)
Genome information
 Approx genome size (bp) 2,104,685 2,040,849 1,995,940 2,003,633
 No. contigs 119 111 447 489
Neisseria PubMLST.org identification number 29312 29306 41961 41860
  1. Abbreviations: COPD chronic obstructive pulmonary disease, C6 sixth complement component, CSF cerebrospinal fluid, S susceptible, R resistant, NG non-groupable, P1 PorA, F FetA, ST sequence type, cc clonal complex, Δ gene deletion
  2. aPatient three presented with two episodes of invasive meningococcal disease in 2011 (episode 1) and 2012 (episode 2, 8 months later), respectively. He was diagnosed with deficiency of the sixth complement component (C6)