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Table 7 Performance comparison of the 10 different algorithms tested on the sub-panel of 191 strains that are represented by three or more strains in the Bruker reference library

From: Decision criteria for MALDI-TOF MS-based identification of filamentous fungi using commercial and in-house reference databases

Threshold

A1

B1

B2

C1

C2

C3

D1

D2

D3

D4

LS 1.5

%accepted

56.02

61.26

48.17

58.12

57.07

38.74

63.35

63.35

53.93

35.08%

species PPV

0.63

0.66

0.59

0.71

0.71

0.64

0.69

0.69

0.66

0.58

genus PPV

0.69

0.72

0.64

0.75

0.74

0.68

0.74

0.74

0.72

0.60

LS 1.6

%accepted

46.07

49.74

36.65

49.74

48.69

31.41

56.54

56.54

47.64

28.80

species PPV

0.76

0.81

0.77

0.83

0.83

0.78

0.77

0.77

0.75

0.71

genus PPV

0.84

0.88

0.84

0.87

0.87

0.83

0.82

0.82

0.81

0.73

LS 1.7

%accepted

38.74

43.98

30.89

43.46

42.41

26.18

46.60

46.60

38.74

20.94

species PPV

0.91

0.92

0.92

0.95

0.95

0.94

0.93

0.93

0.92

0.98

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

LS 1.8

%accepted

24.61

31.94

27.23

31.94

31.41

23.04

33.51

33.51

28.80

18.32

species PPV

0.98

0.95

0.94

0.97

0.97

0.95

0.98

0.98

0.98

1.00

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

LS 1.9

%accepted

17.28

23.04

19.90

21.47

20.94

15.71

23.56

23.56

20.42

15.71

species PPV

0.97

0.95

0.95

1.00

1.00

1.00

1.00

1.00

1.00

1.00

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

LS 2.0

%accepted

12.04

15.71

14.66

14.14

14.14

11.52

13.61

13.61

13.09

11.52

species PPV

1.00

0.97

0.96

1.00

1.00

1.00

1.00

1.00

1.00

1.00

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

LS 2.1

%accepted

6.81

7.85

6.81

8.38

8.38

7.33

7.33

7.33

7.33

6.81

species PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

LS 2.2

%accepted

5.24

6.81

5.76

5.76

5.76

4.71

5.24

5.24

5.24

4.71

species PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

LS 2.3

%accepted

3.14

3.66

2.62

2.09

2.09

1.57

2.09

2.09

2.09

1.57

species PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

genus PPV

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

  1. % accepted: percentage of submitted strains that fulfilled the criteria for identification at either the genus or species level depending on the applied threshold; species PPV: positive predictive value at the species level; genus PPV: positive predictive value at the genus level