Fig. 8

Schematic diagram showing the regulatory network of c-di-GMP signaling regulating csgD expression. At least three distinct groups of c-di-GMP turnover proteins regulate csgD expression. Regulation of csgD by STM1703 occurs on the transcriptional level, while the regulatory level by the other groups is unknown and drawn arbitrarily. The STM1987/STM4551/STM3611 group inversely regulates motility [40]. EAL-like proteins STM1344 and STM1697 affect the c-di-GMP signaling network through post-translational inhibition of FlhD₄C₂, the regulator of the flagellar cascade and regulation of STM1703 [41, 55]. Green represents a diguanylate cyclase, blue a phosphodiesterase and magenta represents a diguanylate cyclase/phosphodiesterase; light grey not directly investigated in this work