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Fig. 8 | BMC Microbiology

Fig. 8

From: A quantitative model for dermal infection and oedema in BALB/c mice pinna

Fig. 8

Experimental conditions for the model. The increase of the ear thickness (oedema) after inoculation was evaluated considering some experimental conditions. The statistical analysis was performed comparing daily the increase of the ear thickness, induced by S. pyogenes in contrast with the PBS control, the deviation bar shows the SEM. a Two independent groups were tested, in both, a little damage was performed at the mouse pinna, we found statistical difference (*) during 8 days post inoculation (n = 8, p <0.0002, non-paired t student test) between S. pyogenes and PBS-control. We evaluated 2 independent groups but without injury, and we did not find difference in the ear thickness between mice inoculated with S. pyogenes or PBS (n = 5). b Two independent groups were compared: mice inoculated with S. pyogenes viable and mice inoculated with S. pyogenes inactivated, both in injured pinna. The inactivated bacteria failed to induce the oedema, and when it was compared with PBS-treated control there was not difference (n = 4 p > 0.15, non-paired t student test). c One group was inoculated in both damaged pinna, one of them were infected with S. pyogenes and the contralateral was de control, treated with PBS, we found statistical difference during 7 days post-inoculation (n = 14, p < 0.0046 paired t student test). d There was no difference between the oedema caused by S. pyogenes in the right or left pinna (n = 8, p > 0.12, paired t student test)

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