Table 1 RAST- annotated genes associating with resistance to antibiotics and toxic compounds
RAST Subsystem | Role (KEGG located number) | Features |
|---|---|---|
Copper homeostasis | Copper-translocating P-type ATPase (EC 3.6.3.4) | peg.608, peg.990, peg.1254 |
Cobalt-zinc-cadmium resistance | Heavy metal RND efflux outer membrane protein, CzcC family | peg.605 |
Cobalt-zinc-cadmium resistance protein | peg.1410 | |
Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family | peg.606 | |
Cobalt-zinc-cadmium resistance protein CzcA | peg.607 | |
Cation efflux system protein CusA | peg.607 | |
Resistance to fluoroquinolones | DNA gyrase subunit B (EC 5.99.1.3) | peg.2036 |
DNA gyrase subunit A (EC 5.99.1.3) | peg.2037 | |
Topoisomerase IV subunit B (EC 5.99.1.-) | peg.888 | |
Topoisomerase IV subunit A (EC 5.99.1.-) | peg.889 | |
Beta-lactamase | Beta-lactamase (EC 3.5.2.6) | peg.1027, peg.1665 |
Metal-dependent hydrolases of the beta-lactamase superfamily I | peg.123 | |
Multidrug Resistance Efflux Pumps | RND efflux system, outer membrane lipoprotein, NodT family | peg.1170 |
RND efflux system, membrane fusion protein CmeA | peg.1631 | |
RND efflux system, outer membrane lipoprotein CmeC | peg.1629 | |
Acriflavin resistance protein | peg.521 | |
Membrane fusion protein of RND family multidrug efflux pump | peg.522 | |
RND efflux system, inner membrane transporter CmeB | peg.1630 | |
Multidrug Resistance Efflux Pumps | Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog | peg.1277 |