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Table 4 MIC of metronidazole resistant strains and the mutation of rdxA and frxA genes

From: Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal

No Strains MIC (mg/L) rdxA frxA
1 2 48 13frameshift R86a
2 4 >256 Q11a 18frameshift
3 5 64 N73a R3T, 54frameshift
4 8 64 Q11a Q5a
5 14 32 R16H, L62V, K190a P2E, R3P, M66I, A70V
6 15 64 K2N, 4frameshift I44T, 47frameshift
7 16 48 E107R, 109frameshift W137a
8 18 128 C148Y undetermined
9 29 >256 R16H, A80T, S108A 18frameshift
10 34 64 undetermined 106frameshift
11 41 16 R16H, R41K, 43frameshift G76R, A152V
12 49 >256 C140Y 18frameshift
13 52 >256 G189S undetermined
14 55 24 L62V, S108A, S196N, Q197a P41L, E176K
15 61 12 None A15V, I144V, M66I
16 64 32 R16H, S108A, R176C, S196N None
17 70 32 K60a D2E, A85V, K178N
18 74 64 S45G 6frameshift
19 83 >256 M21V, A80T, Q119a A70V
20 84 16 Q50a R58H
21 86 96 Q50a R25T, M66I, A154T
22 89 32 Q65a A115V
23 90 64 45frameshift 18frameshift
24 92 >256 C140Y 18frameshift
25 94 64 Q50a undetermined
26 108 128 R16L 18frameshift
27 110 32 None P41L
28 113 128 A40T A16T, I44V, 70frameshift
29 114 >256 Q16a 18frameshift
30 116 >256 G163D 18frameshift
31 120b >256 None None
32 123 >256 Q50a V6a
33 124 >256 D23G 18frameshift
34 137 128 M56I, 201frameshift 70frameshift
35 140 96 60frameshift 71frameshift
36 141 64 S43L 72frameshift
37 142 64 undetermined A15V
  1. Q11a means premature stop codon at Gln11; 13frameshift means frameshift mutation in the amino acid 13; R16H means amino acid substituted at Arg-16; None means no specific mutation; Undetermined is the strains that failed to show identifiable specific bands of rdxA or frxA target in PCR
  2. bHigh MIC values strain without specific mutation in rdxA and frxA but contained mutation in dppA and dapF