Fig. 4

Short-term NAC treatment results in a significant reduction of mycobacterial loads in the lungs from mice infected with M. tuberculosis. a C57BL/6 mice were intratracheally infected with ~ 3 × 10⁴ bacilli of H37Rv strain. Mice were treated or not with NAC (400 mg/kg) by gavage daily for 6 days. b On day 7 p.i., animals were euthanized and lungs were harvested. CFU/g values in lungs were determined as described in Methods. Data represent individual values and means ± SEM from a total of 5 animals per group. Data from two independent experiments are shown. Significant differences were observed for the indicated groups (**p < 0.01)