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Fig. 4 | BMC Microbiology

Fig. 4

From: Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

Fig. 4

L. acidophilus upregulated negative regulators of TLRs signaling pathway in spleen of ETEC-infected piglet. Pigs were challenged with or without ETEC (1 × 109 CFU/kg BW). Three hours post inflammatory challenge, spleen samples were collected to examine the levels of Tollip (A), IRAK-M (B), Bcl-3 (C) and A20 (D) by real-time RT-PCR. Expression of Tollip, IRAK, A20 and Bcl-3 was normalized to β-actin in the same sample, and presented as fold change relative to ETEC-challenged pigs fed with basal diet (ETEC group). Expression of Tollip, IRAK, A20 or Bcl-3 in ETEC group was normalized to 1.0. Values with different letters are significantly different (P < 0.05). (n = 3)

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