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Table 2 Production of organic acids by C. glutamicum WT under nitrogen-limiting conditions in the absence or presence of ciprofloxacin

From: Ciprofloxacin triggered glutamate production by Corynebacterium glutamicum

Ciprofloxacin [μg/ml] Cell dry weight [mg/ml] Acetate [mM] Lactate [mM] glutamate [mM] 2-oxoglutarate [mM]
0 6 ± 1 7 ± 2 7 ± 1 0 ± 1 7 ± 1
16 6 ± 1 10 ± 1 6 ± 1 4 ± 1 19 ± 1
  1. Cells were cultivated in CGXII containing ten times less nitrogen sources than regular CGXII medium. 1 % glucose was used as carbon and energy source. At an OD600 of about 15, no or 16 μg/ml ciprofloxacin were added. The concentration of organic acids was determined after glucose depletion. All values represent the mean and the standard error of triplicates