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Table 1 Differential gene expression of C. glutamicum caused by ciprofloxacin

From: Ciprofloxacin triggered glutamate production by Corynebacterium glutamicum

Gene IDa Gene namea Function of proteina M-valueb P-value*
DNA synthesis, repair, modification
 cg2141 recA Recombinase A 3.86 0.000
 cg1996 cglIM DNA (cytosine-5-)-methyltransferase 3.41 0.000
 cg0886 - Putative ATP-dependent DNA helicase superfamily II 2.41 0.003
 cg1401 ligA DNA ligase (NAD(+)) 2.16 0.002
 cg1400 - Putative DNA polymerase III, Gram-positive-type alpha subunit 2.01 0.002
 cg1997 cglIR Putative type II restriction endonuclease 1.38 0.001
 cg0885 - Putative helicase, UvrD/Rep-family 1.08 0.029
 cg2509 recO DNA repair protein RecO 1.05 0.044
 cg1316 - DNA/RNA helicase, SNF2 family 1.03 0.022
 cg1018 - Putative ATP-dependent DNA helicase 3.12 0.001
 cg2950 radA Putative ATP-dependent protease involved in DNA repair 1.10 0.029
Transcription, Translation, Proteinmodification
 cg2114 lexA transcriptional regulator, LexA-family 1.61 0.004
 cg3071 pyrE Orotate phosphoribosyltransferase 1.38 0.025
 cg0684 papA Prolyl aminopeptidase A 1.31 0.006
 cg0685 - Conserved hypothetical protein similar to metal-dependent proteases, putative molecular chaperone 1.66 0.003
 cg0686 - Putative acetyltransferase, GNAT-family 1.32 0.013
 cg1980 - Hypothetical protein, MoxR-like ATPase 1.33 0.006
Genes of unknown function
 cg2113 divS Cell division suppressor DivS 5.38 0.000
 cg2381 - Conserved hypothetical protein 3.86 0.000
 cg1287 - Conserved hypothetical protein 3.09 0.008
 cg1962 - Putative membrane protein 2.56 0.000
 cg0839 - Hypothetical protein 2.52 0.001
 cg1977 - Putative secreted protein 1.95 0.000
 cg2026 - Hypothetical protein 1.88 0.000
 cg1978 - Hypothetical protein 1.72 0.000
 cg1917 - Hypothetical protein 1.50 0.002
 cg0841 - Conserved hypothetical protein 1.39 0.016
 cg1743 - Conserved hypothetical protein 1.38 0.006
 cg1937 - Putative secreted protein 1.22 0.015
 cg3018 - Hypothetical protein 1.22 0.002
 cg0451 - Putative membrane protein 1.21 0.003
 cg0712 - Putative secreted protein 1.08 0.014
 cg3106 - Conserved hypothetical protein 1.03 0.029
 cg2391 aroG 3-Deoxy-7-phosphoheptulonate synthase -1.26 0.022
 cg0203 iolE Putative myo-inosose-2 dehydratase -1.25 0.009
 cg1342 narJ Respiratory nitrate reductase 2, delta chain -1.13 0.041
 cg2378 mraZ Putative MraZ protein -1.13 0.023
 cg2118 fruR transcriptional regulator of fructose metabolism -1.08 0.014
 cg0205 iolH Myo-inositol catabolism protein -1.06 0.044
Genes of unknown function
 cg1918 - Putative secreted protein -2.82 0.000
 cg2080 - Conserved hypothetical protein -1.74 0.012
 cg2952 - Putative secreted protein -1.58 0.002
 cg0045 - ABC-type putative sugar transporter, permease subunit -1.36 0.025
 cg1884 - Putative membrane protein -1.30 0.038
 cg1340 - Conserved hypothetical protein -1.27 0.001
 cg3226 - Putative MFS-type L-lactate permease -1.15 0.009
  1. aGene ID, gene name and function of proteins are given according to CoryneRegNet (http://coryneregnet.de). bRelative RNA levels of cells treated with 4 μg∙ml-1 ciprofloxacin compared to untreated cells are shown as log 2 values (M-values). * P-values were determined by Student’s t-test. Only genes with significant (p < 0.05) expression differences and M-values >1 or <1 are listed. The wild type was cultured in triplicate in CGXII with 1 % (w/v) glucose to an OD600 of about 5. Afterwards, cells were exposed to 4 µg/ml ciprofloxacin, a concentration allowing minor growth of the cultures. The data are available as Gene Expression Omnibus GSE77189 data set at http://www.ncbi.nlm.nih.gov/geo/