Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations

BMC Microbiology

Table 1 Background information of the patients

	Patient
	TPF1	sAH
Diagnosis	Fibrosing cholestatic hepatitis	Acute hepatitis
Genotype	1b	1b
Response of IFN treatment^a	NR	SVR
HCV RNA in serum (copies/mL)	4.0 × 10⁷	1.3 × 10⁵
Core 70/91^b	Mutant/Wild	Wild/Wild
ISDR (a.a.2209–2248)^c	Wild	Wild
IRRDR (a.a.2234–2379)^d	5	5
Subgenome^e	Yes	No

^a NR non responder, SVR sustaind virologic response
^bPretreatment predictor of poor virologic response [51]
^cIFN sensitivity-determining region [52]
^dIFN/RBV resistance-determining region [53]
^eLarge in-frame deletions of E1/E2 proteins in specimens of chronically infected patients [33]

ISSN: 1471-2180