Fig. 1

Pharmacodynamic model with four parameters. The bacterial growth rates (ψ) in response to each antimicrobial concentration are estimated from time-kill data with linear regression. The maximal bacterial growth rate ψ _max, the minimal bacterial growth rate at high concentrations of antimicrobial ψ _min, the pharmacodynamic MIC (zMIC) and the Hill coefficient к are shown and define the shape of the curve