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Table 2 Minimum Inhibitory Concentrations of AvBD-6 and AvBD-12a

From: Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges

Microorganism Source (Number of strains) AvBD-6 AvBD-12
MIC MIC-ls MIC MIC-ls
Gram-negative
E. coli ATCC 25922 (1) 128 4 256 32
E. coli Clinical isolates (10) 256 ≤8 256 ≤64
S. enterica serovar Typhimurium ATCC 14028 (1) ≥256 16 >256 128
K. pneumoniae Clinical isolates (10) ≥256 ≤16 >256 ≤64
Gram-positive
S. aureus ATCC 29213 (1) 256 128 >256 256
S. pseudinetrmedius Clinical isolates (10) ≥256 ≥256 >256 ≥256
  1. aMinimum inhibitory concentrations (μg/ml) were determined using the CLSI broth microdilution method and the modified broth microdilution method using low salt Muller Hinton Broth (MIC-ls) as described in materials and methods section. Clinical isolates were received from the Clinical Veterinary Microbiology Laboratory of Texas A&M University