Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges

BMC Microbiology

Table 2 Minimum Inhibitory Concentrations of AvBD-6 and AvBD-12^a

Microorganism	Source (Number of strains)	AvBD-6		AvBD-12
Microorganism	Source (Number of strains)	MIC	MIC-ls	MIC	MIC-ls
Gram-negative
E. coli	ATCC 25922 (1)	128	4	256	32
E. coli	Clinical isolates (10)	256	≤8	256	≤64
S. enterica serovar Typhimurium	ATCC 14028 (1)	≥256	16	>256	128
K. pneumoniae	Clinical isolates (10)	≥256	≤16	>256	≤64
Gram-positive
S. aureus	ATCC 29213 (1)	256	128	>256	256
S. pseudinetrmedius	Clinical isolates (10)	≥256	≥256	>256	≥256

^aMinimum inhibitory concentrations (μg/ml) were determined using the CLSI broth microdilution method and the modified broth microdilution method using low salt Muller Hinton Broth (MIC-ls) as described in materials and methods section. Clinical isolates were received from the Clinical Veterinary Microbiology Laboratory of Texas A&M University

ISSN: 1471-2180