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Fig. 6 | BMC Microbiology

Fig. 6

From: Combining Shigella Tn-seq data with gold-standard E. coli gene deletion data suggests rare transitions between essential and non-essential gene functionality

Fig. 6

Three genes involved in proline biosynthesis (proABC) appear uniquely essential in Shigella. The orthologous E. coli deletion strains exhibit robust growth (OD600 greater than 0.75 after 22 h growth in LB), but are essential by our criteria. proA and proC completely lack transposon insertions, while proB contains only two insertions near the 3′end, which leaves approximately 70 % of the gene intact, including the entire kinase and substrate-binding domain

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BMC Microbiology

ISSN: 1471-2180

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