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Table 3 Minimum inhibitory concentration (MIC) of oxacillin, α-mangostin, and nisin alone and in combination

From: Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus

Strains MIC (μg/ml) FIC (μg/ml) FIC index
OXA AMT NIS OXA + AMT OXA + AMT
S. saprophyticus DMST 27055 128 R 8 256 16 + 2 0.37 SI
S. saprophyticus DMST 27058 128 R 8 256 16 + 2 0.37 SI
S. saprophyticus DMST 4236 128 R 8 256 16 + 2 0.37 SI
S. saprophyticus DMST 4672 128 R 8 256 16 + 2 0.37 SI
S. saprophyticus DMST 5057 128 R 8 256 16 + 2 0.37 SI
S. saprophyticus DMST 8034 128 R 8 256 16 + 2 0.37 SI
S. aureus ATCC 29213P 0.5 S 4 1 N/D N/D
  1. S. aureus ATCC 29213 P, was used as a positive control
  2. S Susceptible, R Resistant, SI Synergistic interaction, N/D Not determine
  3. OXA Oxacillin, AMT α-mangostin, NIS Nisin
  4. The MICs are presented as the median values measured from three independent experiments; each experiment was performed in triplicate