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Table 2 An example of translational efficiencies of HCV IRESs containing variations of some hypervariable and/or conserved nucleotides as revealed from the HCVIVdb data analysis

From: HCVIVdb: The hepatitis-C IRES variation database

Hypervariable nucleotides Translational activity % References
A 204 C ~100 [20]
C 204 U 109 ± 9 [22]
C 204 U ~80 [21]
U 204 A Retains full activity [23]
A 243 G 92 [20]
G 203 A + G 243 A 100 [20]
C 204 A + G 243 A 83 [21]
Conserved nucleotides Translational activity % References
G 266 A 5 [25]
G 266 C 3 [23]
G 267 C >95 reduction in activity [24]
G 267 C 2 [23]
G 268 C >95 reduction in activity [24]
G 268 C 3 [23]