Skip to main content

Table 2 Interactive effects of Chinese herbal active ingredients with cefotaxime on antibiotic resistant K. pneumoniae

From: Synergistic effects of baicalein with cefotaxime against Klebsiella pneumoniae through inhibiting CTX-M-1 gene expression

Strains No. MICalone(μg/mL) MICcombined(μg/mL) aFICI MICcombined(μg/mL) aFICI MICcombined(μg/mL) aFICI
bBai cMat dCla Cefotaxime bBai cefotaxime cMat cefotaxime dCla cefotaxime
28 >256 >256 16 128 128 128 1.5 2 128 1.008 0.5 4 0.063*
30 >256 >256 8 128 64 64 0.75* 2 128 1.008 0.5 4 0.094*
58 >256 >256 32 256 128 128 1 2 256 1.008 0.5 8 0.047*
64 >256 >256 32 256 1 256 1.004 2 256 1.008 0.5 8 0.047*
80 >256 >256 32 512 64 256 0.75* 2 1024 2.008 0.5 16 0.047*
90 >256 >256 8 1024 128 1024 1.5 2 1024 1.008 0.5 32 0.094*
102 >256 >256 16 128 32 64 0.63* 2 128 1.008 0.5 4 0.063*
116 >256 >256 8 128 128 64 1 2 128 1.008 0.5 4 0.094*
171 >256 >256 16 128 128 64 1 2 128 1.008 0.5 4 0.063*
179 >256 >256 8 1024 64 256 0.5* 2 1024 1.008 0.5 32 0.094*
210 >256 >256 8 256 128 64 0.75* 2 256 1.008 0.5 8 0.094*
219 >256 >256 8 1024 1 1024 1.004 2 1024 1.008 0.5 32 0.094*
796 >256 >256 8 256 32 64 0.38* 2 256 1.008 0.5 8 0.094*
826 >256 >256 8 1024 128 256 0.75* 2 1024 1.008 0.5 32 0.094*
863 >256 >256 8 256 128 64 0.75* 2 256 1.008 0.5 8 0.094*
700603 >256 >256 8 4 4 2 0.52* 2 4 1.010 1 1 0.38*
  1. *FICI ≤0.75 means synergy group including both synergy and partial synergy
  2. aFICI≤0.5 synergy, 0.5 <FICI≤0.75 partial synergy, 0.76 <FICI≤1 additive, 1 <FICI≤4 indifferent, FICI> 4 antagonistic
  3. bBai:baicalein; cMat:matrine; dCla:clavulanate acid