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Table 2 INH-Resistance conferring mutations in 180 INH-R (85 %) and 32 INH-S (15 %) isolates

From: Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012

Drug resistance

Genes

No. of isolates

Changes

INHR

 

180

Nucleotides

Amino acid

  

3

katG

   

Single mutation

  

1

GTC/GGC

V284Ga

  

1

AGC/AAC

S315N

  

1

AGC/GGC

S315G

  

78

AGC/ACC

S315T

 

katG

1

CCG/CGG

P375Ra

  

1

TAC/TGC

Y413Ca

  

1

del G1284

frameshifta

  

1

TGG/TCG

W438S

  

1

GAC/AAC

D448Na

   

Multiple mutations

  

1

AGC/ACC, TGA/TAA

S315T, 343Stop

  

1

AGC/ACC, GAT/CAT

S315T, D387Hb

  

1

AGC/ACC, GTC/GAC

S315T, V450Db

  

1

AGC/ACC, GGC/AGC

S315T, G451Sb

   

Single mutations

 

inhA

3

TCG/GCG

S94A

  

1

-8 T/C

None

 

inhA-p

37

-15C/T

None

  

3

-17G/T

None

   

Multiple mutations

 

inhA-p

1

-15C/T, -47 G/T

None

 

inhA, inhA-p

1

GGA/GGC, -15C/T

G3G, None

 

2

ATC/ACC, -15C/T

I21T, None

  

3

ATC/GTC, -15C/T

I21V, None

 

katG, inhA

1

AGC/ACC, GGA/GGC

S315T, G3G

  

3

GAA/GAC, -15C/T

E261D, None

 

katG, inhA-p

1

CCG/TCG, -15C/T

P280Sb, None

 

1

TCG/GCG, -15C/T

S303Ab, None

 

1

ACC/GCC, -15C/T

T314A, None

  

1

AGC/AAC, -47G/C

S315N, None

  

2

AGC/ACC, -8 T/A

S315T, None

  

3

AGC/ACC, -8 T/C

S315T, None

  

2

AGC/AAC, -15C/T

S315T, None

  

1

AGC/AAC, -102G/A

S315T, None

  

1

ACT/ATT, -15C/T

T308I, None

 

katG, inhA, inhA-p

19

WT

None

INHS

katG, inhA, inhA-p

32

WT

None

  1. aUndescribed mutations that occur alone; bundescribed mutations that occur in combination with another resistance-associated mutation; inhA-p, inhA promoter, del, deletion; WT wild-type sequence, R resistant, S susceptible