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Table 2 Phenotypic and molecular characteristics of CRE and CPE isolates from fecal samples

From: Risk factors for fecal carriage of carbapenemase producing Enterobacteriaceae among intensive care unit patients from a tertiary care center in India

  Controls ICU
D1 D4
Total Enteterobacteriaceae isolated (n = 444) 181 145 118
Characteristics of CRE (n = 91) 20 31 40
 1. Species distribution pattern
   Escherichia coli 16 28 30
   Klebsiella sp. 2 3 9
   Proteus sp. 2 0 0
   Enterobacter sp. 0 0 1
 2. MIC range (mg/L)
  Ertapenem 0.75-64 0.75-64 0.75-64
  Imipenem 0.25-64 0.25-64 0.25-64
  Meropenem 0.064-64 0.047-64 0.064-64
 3. Phenotypic characterization
  MBL 10 11 15
  KPC 0 0 2
  Non MBL/KPC Carbapenemase 0 3 9
  Only ESBL and/or AmpC 10 15 11
  No β lactamases class 0 2 3
Characteristics of CPE isolates (n = 50) 10 14 26
 1. Species distribution pattern    
   Escherichia coli 6* 14¥ 19$
   Klebsiella sp. 2* 0 6 ҍ
   Proteus sp. 2* 0 0
   Enterobacter sp. 0 0 1#
 2. MIC range (mg/L)    
  Ertapenem 64-64 3-64 2-64
  Imipenem 64-64 0.38-64 0.38-64
  Meropenem 64-64 0.5-64 0.38-64
 3. Distribution of β- lactamases    
  TEM 4 10 14
  SHV 1   4
  CTXM 2 9 22
  CIT 1   1
  DHA 2 3  
  MOX    2
  NDM-1 10 12 17
  KPC    2
  OXA-48   1 7
  OXA-181   2 8
Characteristics of NON-CPE isolates (n = 41) 10 17 14
 1. Species distribution pattern
   Escherichia coli 10 14 11
   Klebsiella sp.   3 3
 2. MIC range (mg/L)
  Ertapenem 0.75-8 0.75-64 0.75-64
  Imipenem 0.25-2 0.25-64 0.25-64
  Meropenem 0.064-0.75 0.047-64 0.064-64
 3. Distribution of β- lactamases
  TEM 5 9 9
  CTXM 6 8 7
  DHA    1
  EBC   1  
  CIT 5   
  No enzyme detected 2 3 2
  1. CRE carbapenem resistant Enterobacteriaceae, CPE carbapenemase producing Enterobacteriaceae, Non CPE non carbapenemase producing Enterobacteriaceae, D1 Day 1, D4 Day 4. *All NDM -1 (n = 10); ¥NDM-1 (n = 11), OXA-48(n = 1), OXA-48 + NDM-1(n = 1), OXA-181(n = 1); $NDM-1(n = 12), OXA-48 + 181(n = 4), OXA-48(n = 1), OXA-48 + NDM-1(n = 1), OXA-48 + 181 + NDM-1(n = 1); ҍ NDM-1(n = 3), KPC (n = 1), OXA-48,181(n = 1), KPC + OXA-181(n = 1); #OXA-181(n = 1)