Risk factors for fecal carriage of carbapenemase producing Enterobacteriaceae among intensive care unit patients from a tertiary care center in India

Table 2 Phenotypic and molecular characteristics of CRE and CPE isolates from fecal samples

	Controls	ICU
	Controls	D1	D4
Total Enteterobacteriaceae isolated (n = 444)	181	145	118
Characteristics of CRE (n = 91)	20	31	40
1. Species distribution pattern
Escherichia coli	16	28	30
Klebsiella sp.	2	3	9
Proteus sp.	2	0	0
Enterobacter sp.	0	0	1
2. MIC range (mg/L)
Ertapenem	0.75-64	0.75-64	0.75-64
Imipenem	0.25-64	0.25-64	0.25-64
Meropenem	0.064-64	0.047-64	0.064-64
3. Phenotypic characterization
MBL	10	11	15
KPC	0	0	2
Non MBL/KPC Carbapenemase	0	3	9
Only ESBL and/or AmpC	10	15	11
No β lactamases class	0	2	3
Characteristics of CPE isolates (n = 50)	10	14	26
1. Species distribution pattern
Escherichia coli	6*	14^¥	19^$
Klebsiella sp.	2*	0	6 ^ҍ
Proteus sp.	2*	0	0
Enterobacter sp.	0	0	1^#
2. MIC range (mg/L)
Ertapenem	64-64	3-64	2-64
Imipenem	64-64	0.38-64	0.38-64
Meropenem	64-64	0.5-64	0.38-64
3. Distribution of β- lactamases
TEM	4	10	14
SHV	1		4
CTXM	2	9	22
CIT	1		1
DHA	2	3
MOX			2
NDM-1	10	12	17
KPC			2
OXA-48		1	7
OXA-181		2	8
Characteristics of NON-CPE isolates (n = 41)	10	17	14
1. Species distribution pattern
Escherichia coli	10	14	11
Klebsiella sp.		3	3
2. MIC range (mg/L)
Ertapenem	0.75-8	0.75-64	0.75-64
Imipenem	0.25-2	0.25-64	0.25-64
Meropenem	0.064-0.75	0.047-64	0.064-64
3. Distribution of β- lactamases
TEM	5	9	9
CTXM	6	8	7
DHA			1
EBC		1
CIT	5
No enzyme detected	2	3	2

CRE carbapenem resistant Enterobacteriaceae, CPE carbapenemase producing Enterobacteriaceae, Non CPE non carbapenemase producing Enterobacteriaceae, D1 Day 1, D4 Day 4. *All NDM -1 (n = 10); ^¥NDM-1 (n = 11), OXA-48(n = 1), OXA-48 + NDM-1(n = 1), OXA-181(n = 1); ^$NDM-1(n = 12), OXA-48 + 181(n = 4), OXA-48(n = 1), OXA-48 + NDM-1(n = 1), OXA-48 + 181 + NDM-1(n = 1); ^ҍ NDM-1(n = 3), KPC (n = 1), OXA-48,181(n = 1), KPC + OXA-181(n = 1); ^#OXA-181(n = 1)

ISSN: 1471-2180