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Fig. 4 | BMC Microbiology

Fig. 4

From: The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms

Fig. 4

Calcineurin inhibitor CsA and FLC synergistically decrease cellular surface hydrophobicity (CSH) of clinical C. albicans isolates. Clinical C. albicans isolates were cultured in the presence of 32 μg/mL FLC or 75 μg/mL of CsA alone, or a combination of CsA and FLC for 24 h prior to be used for CSH measurement. The combination of CsA and FLC caused significantly decrease of CSH of C. albicans cells, although CsA or FLC along also had a moderate effect on the reduction of CSH. Compared to the untreated control, and treated with CsA or FLC alone groups, **: p < 0.01. Data represented the mean ± SD from three independent triplicated experiments (N = 9)

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BMC Microbiology

ISSN: 1471-2180

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