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Fig. 3 | BMC Microbiology

Fig. 3

From: The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms

Fig. 3

A combination of calcineurin inhibitor CsA and FLC down-regulated the expression of biofilm-related and drug transporter in clinical C. albicans isolates. Clinical C. albicans isolates were cultured in 6-well plates with 32 μg/mL FLC and 75 μg/mL of CsA alone or in combination for 24 h. The expression of indicated genes was determined by a qRT-PCR assay. The combination of CsA and FLC significantly inhibited the expression of all tested genes, although CsA or FLC along also could moderately down-regulated the expression of these genes. Compared with the untreated group, FLC alone group, a: p < 0.05; compared with the CsA or FLC alone group, b: p < 0.01. Data represented the mean ± SD from three independent triplicated experiments (N = 9)

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