Fig. 4
From: Pneumococcal colonization and invasive disease studied in a porcine model
Systemic pro-inflammatory immune responses in piglets infected with S. pneumoniae. Serum concentrations of IL-1-β (panel a) and IL-6 (panel b) were determined by ELISA for piglets inoculated intravenously with a high dose of S. pneumoniae (open circles, dotted line) or intranasally with a high dose of S. pneumoniae (closed circles, solid line). Each symbol represents 3 – 5 piglets, error bars show standard deviation. *** p < 0.001 (ANOVA)