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Table 4 Central Composite Design in coded units

From: Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation

Run Initial pH (A) Temperature (B) Peptone (C) MgSO4.7H2O (D) Metabolite yield (mg/l)
1 0 0 0 0 217.56
2 −1 1 −1 −1 70.34
3 0 0 0 2 67.8
4 −1 1 −1 1 73.78
5 1 −1 1 −1 73.78
6 1 1 −1 1 55
7 0 0 0 0 210.7
8 1 1 1 1 32.15
9 0 −2 0 0 71.32
10 0 0 0 0 210.65
11 0 0 0 0 217.5
12 1 1 −1 −1 66.2
13 −1 −1 1 −1 77.7
14 0 0 2 0 80.25
15 1 −1 1 1 75.2
16 0 0 0 0 205.5
17 1 1 1 −1 75
18 1 −1 −1 1 80.14
19 −1 1 1 1 62
20 2 0 0 0 80
21 −1 −1 1 1 66.5
22 −1 −1 −1 −1 78.5
23 0 0 0 0 205.46
24 0 0 0 −2 77.58
25 0 0 −2 0 51.3
26 −1 −1 −1 1 70.85
27 1 −1 −1 −1 46.76
28 0 2 0 0 48
29 −2 0 0 0 70
30 −1 1 1 −1 78.45