Antimicrobial susceptibility testing of Neisseria gonorrhoeae isolates in Pakistan by Etest compared to Calibrated Dichotomous Sensitivity and Clinical Laboratory Standards Institute disc diffusion techniques

Table 2 Antimicrobial susceptibility results of Neisseria gonorrhoeae isolates by CDS/CLSI disc diffusion and MIC by Etest (n = 100)

Methods	Penicillin G %			Ciprofloxacin %			Ceftriaxone %			Tetracycline %			Spectinomycin %			Azithromycin %
	S	I	R	S	I	R	S	I	R	S	I	R	S	I	R	S	I	R
Etest MIC	08	49	43	00	14	86	100	00	00	12	37	51	100	00	00	99	00	01
CLSI/BSAC^a MIC break points (μg/ml)	≤0.06	0.12-1	≥2	≤0.06	0.12-0.5	≥1	≤0.25	-	-	≤0.25	0.5–1	≥2	≤32	64	≥128	≤0.25	0.5	≥0.5
CDS disc diffusion	10	13	77	00	20	80	100	00	00	NP	NP	NP	100	00	00	99	00	01
CDS annular radius break points (mm)	>9	3-9	<3	≥11	6-10	<6	≥10	-	5-9	NP	NP	NP	≥6	-	<6	≥8	-	<8
CLSI disc diffusion	04	34	62	00	04	96	100	00	00	03	40	57	100	00	00	99	00	01
CLSI/BSAC^a zone diameter break points (mm)	≥47	27-46	≤26	>41	28-40	≤27	≥35	-	-	≥38	31-37	<30	≥18	15-17	≤4	≥28	-	≤27

ISSN: 1471-2180