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Table 2 Antimicrobial susceptibility results of Neisseria gonorrhoeae isolates by CDS/CLSI disc diffusion and MIC by Etest (n = 100)

From: Antimicrobial susceptibility testing of Neisseria gonorrhoeae isolates in Pakistan by Etest compared to Calibrated Dichotomous Sensitivity and Clinical Laboratory Standards Institute disc diffusion techniques

Methods Penicillin G % Ciprofloxacin % Ceftriaxone % Tetracycline % Spectinomycin % Azithromycin %
  S I R S I R S I R S I R S I R S I R
Etest MIC 08 49 43 00 14 86 100 00 00 12 37 51 100 00 00 99 00 01
CLSI/BSACa MIC break points (μg/ml) ≤0.06 0.12-1 ≥2 ≤0.06 0.12-0.5 ≥1 ≤0.25 - - ≤0.25 0.5–1 ≥2 ≤32 64 ≥128 ≤0.25 0.5 ≥0.5
CDS disc diffusion 10 13 77 00 20 80 100 00 00 NP NP NP 100 00 00 99 00 01
CDS annular radius break points (mm) >9 3-9 <3 ≥11 6-10 <6 ≥10 - 5-9 NP NP NP ≥6 - <6 ≥8 - <8
CLSI disc diffusion 04 34 62 00 04 96 100 00 00 03 40 57 100 00 00 99 00 01
CLSI/BSACa zone diameter break points (mm) ≥47 27-46 ≤26 >41 28-40 ≤27 ≥35 - - ≥38 31-37 <30 ≥18 15-17 ≤4 ≥28 - ≤27
  1. S sensitive, I intermediate, R resistant
  2. NP not performed
  3. aBSAC breakpoints were used for Azithromycin