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Table 2 Antimicrobial susceptibility results of Neisseria gonorrhoeae isolates by CDS/CLSI disc diffusion and MIC by Etest (n = 100)

From: Antimicrobial susceptibility testing of Neisseria gonorrhoeae isolates in Pakistan by Etest compared to Calibrated Dichotomous Sensitivity and Clinical Laboratory Standards Institute disc diffusion techniques

Methods

Penicillin G %

Ciprofloxacin %

Ceftriaxone %

Tetracycline %

Spectinomycin %

Azithromycin %

 

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

Etest MIC

08

49

43

00

14

86

100

00

00

12

37

51

100

00

00

99

00

01

CLSI/BSACa MIC break points (μg/ml)

≤0.06

0.12-1

≥2

≤0.06

0.12-0.5

≥1

≤0.25

-

-

≤0.25

0.5–1

≥2

≤32

64

≥128

≤0.25

0.5

≥0.5

CDS disc diffusion

10

13

77

00

20

80

100

00

00

NP

NP

NP

100

00

00

99

00

01

CDS annular radius break points (mm)

>9

3-9

<3

≥11

6-10

<6

≥10

-

5-9

NP

NP

NP

≥6

-

<6

≥8

-

<8

CLSI disc diffusion

04

34

62

00

04

96

100

00

00

03

40

57

100

00

00

99

00

01

CLSI/BSACa zone diameter break points (mm)

≥47

27-46

≤26

>41

28-40

≤27

≥35

-

-

≥38

31-37

<30

≥18

15-17

≤4

≥28

-

≤27

  1. S sensitive, I intermediate, R resistant
  2. NP not performed
  3. aBSAC breakpoints were used for Azithromycin