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Table 1 Metabolic pathway-independent druggable proteins

From: Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen protein-protein interactions

S. No. Gene Protein name Uniprot ID Function
1 FN1275 Acriflavin resistance protein B Q8RE51 Resistant to aminoglycosides such as amikacin, gentamycin, kanamycin, neomycin and tobromycin as well as to amphiphilic compounds. Thus, inhibiting AcrB function may lead to pathogen’s susceptibility to these antibiotics.
2 FN1321 Acetoacetate metabolism regulatory protein atoC Q8RE11 Required for catabolism of short-chain fatty acids. Plays role in flagella synthesis, sodium (but not potassium) sensitivity and chemotaxis.
3 ftsZ Cell division protein FtsZ Q8RDQ7 Required for proper localization of division plane during bacterial cytokinesis. Inhibition of its GTP-dependent polymerization activity prevents cells to divide
4 FN0724 Flavodoxin Q8RFH4 Acts as an electron acceptor of pyruvate-oxidoreductase complex. Flavodoxin inhibitors were reported to act against Helicobacter pylori’s infection that causes gastritis or chronic peptic ulcers
5 FN0756 Pseudouridine synthase Q8RFE9 Catalyze post-transcriptional modifications of cellular RNAs i.e., site-specific isomerisation of uridine.
6 rsgA Putative ribosome biogenesis GTPase RsgA Q8R685 Involved in 30S ribosome subunit biogenesis.
7 FN0809 Putative tRNA (cytidine(34)-2’-O)-methyltransferase Q8R673 Methylates 2’-O-ribose group of cytidine present at 34thposition of tRNA anticodon loop.
8 sigA RNA polymerase sigma factor SigA Q8RE13 Essential for survival of bacteria as it regulates transcription of housekeeping promoters.