Fig. 7
From: Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics
Prediction of the antibiotic mode of action. PLS-DA scores plot of fingerprints of E. coli cultures incubated with a doxycycline, kanamycin and H2O for 30 min (6 components, R2 = 0.99, Q2 = 0.90). Using this model as reference data set fingerprints of cultures incubated with b tetracycline, c streptomycin and d carbenicillin were predicted according to their mode of action. Tetracycline and doxycycline resulted in similar fingerprints as well as kanamycin and streptomycin. Carbenicillin, an antibiotic which inhibits the cell wall showed strong similarities to the control group. N = 6 for each compound