Fig. 3
From: Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics
Multivariate statistical analysis of metabolic fingerprints and footprints derived from E. coli cultures after antibiotic treatment. a PLS-DA scores plot (3 components, R2 = 0.76, Q2 = 0.65) of intracellular metabolic profiles of E. coli cultures after incubation with antibiotics with intra- (ciprofloxacin, kanamycin, doxycycline) and extracellular (ampicillin, cefalexin) action for 30 min. b PLS-DA scores plot (5 components, R2 = 0.88, Q2 = 0.49) of fingerprints treated with ampicillin and cefalexin compared to controls and c PLS-DA scores plot of footprints corresponding to a (7 components, R2 = 0.72, Q2 = 0.48). N = 6 for each compound