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Fig. 7 | BMC Microbiology

Fig. 7

From: The GAS PefCD exporter is a MDR system that confers resistance to heme and structurally diverse compounds

Fig. 7

A schematic depiction of heme-tolerance transporters described in streptococci. Putative homologs of the HrtAB (Class-3 ABC-type transporter) were identified in GBS, and were shown to be induced by heme. The PefAB and PefCD are heme and PPIX efflux machineries used by GBS. PefAB is related to the drug/proton antiporter family, while PefCD consists of Class-1 ABC type transporter. Our data show that GAS employs PefCD to efflux heme and various antibacterial compounds

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BMC Microbiology

ISSN: 1471-2180

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