Protective hybrid coating containing silver, copper and zinc cations effective against human immunodeficiency virus and other enveloped viruses

Table 2 Anti-HIV-1 activity of hybrid coating on glass coverslips

	Exposure time [min]	HIV-1 titer [TCID₅₀/ml] after exposure to uncoated and coated coverslip and after washing with 0.49 ml of PBS			HIV-1 titer reduction^a	p-value^b
	Exposure time [min]	Coverslip #1	Coverslip #2	Coverslip #3	HIV-1 titer reduction^a	p-value^b
Uncoated coverslip	5	3981	3981	3981	-	-
Uncoated coverslip	20	3981	1000	3981	-	-
Coated coverslip by heat polymerization	5	251	1259	1000	79 %	<0.001
Coated coverslip by heat polymerization	20	316	251	316	90 %	<0.05
Coated coverslip by photopolymerization	5	63	63	63	98 %	<0.001
Coated coverslip by photopolymerization	20	0	20	0	99.8 %	<0.05

^aHIV-1 titer reduction was calculated from average HIV-1 titers from uncoated coverslips set as 100 % minus the quotient between residual average HIV-1 titers from coated coverslips and average titers from uncoated coverslips expressed in percentage
^bOne way analysis of variance test between HIV-1 titers obtained from uncoated coverslips versus coated coverslips at given exposure time

ISSN: 1471-2180