Thionin-like peptide from Capsicum annuum fruits: mechanism of action and synergism with fluconazole against Candida species

Table 3 Inhibition percentage of yeast species treated with CaThi and FLC alone and in combination showing synergism effect in vitro

Yeasts species	Sample	Concentration (μg.mL⁻¹)^a	Inhibition (%)	Combination inhibition (%) (CaThi + FLC)^b
C. albicans	CaThi	3.5	2.93	77.5
C. albicans	FLC	0.5	24.48	77.5
C. tropicalis	CaThi	3.5	0	96.26
C. tropicalis	FLC	0.5	11.55	96.26
C. parapsilosis	CaThi	3.5	4.0	100.0
C. parapsilosis	FLC	0.5	50	100.0
C. pelliculosa	CaThi	15.0	2.63	57.45
C. pelliculosa	FLC	2.5	7.8	57.45
C. buinensis	CaThi	5.0	19.0	67.01
C. buinensis	FLC	0.06	5.45	67.01
C. mogii	CaThi	10.0	17.19	61.05
C. mogii	FLC	1.0	22.80	61.05

^a CaThi concentrations ranging 1.3 to 4.0 times below it IC₅₀ and FLC concentrations 2.0 times below it IC₅₀ or at it IC₅₀
^bIndicates significance by the ANOVA test (P < 0.05) which were calculated by the absorbance values of synergism among the experiments and their respective controls

ISSN: 1471-2180