Table 1 List of the model parameters

k _flow

the flow rate constant

1.65 · 10⁻⁴ s⁻¹

(1)

[1]

δ _{nrf, 1}

parameters of the m _nrf generalized function that describes the nrf operon activity changes in relation to the nitrite concentration established in the chemostat

60

(6)

[1], [35]

K _{nrf ,1}

0.36 mM

h _{nrf ,1}

1.3

δ _{nrf, 2}

0.16

K _{nrf ,2}

1.7 mM

h _{nrf ,2}

3.0

ks _Nrf

the maximum specific rate of the NrfA and NrfB proteins synthesis

1.13 10⁻⁵ mM/s

(6)

[*]^b

ks _NirC

the maximum specific rate of the NirC potein synthesis

7.3 · 10⁻⁵

mM/s

(6)

$\begin{array}{l}k{s}_{\mathit{NirB}}=\\ =k{s}_{\mathit{NirD}}\end{array}$

the maximum specific rate of the NirB and NirD proteins synthesis

$\begin{array}{l}k{s}_{\mathit{NirB}}=\\ =k{s}_{\mathit{NirC}}/5\end{array}$

(6)

k _{d ,} Nrf

the rate constant for the NrfA and NrfB monomers degradation in cytoplasm

9.6 10⁻⁵ s⁻¹

(11)

[29]

kt _{Nrf ,} cp

the rate constant for the NrfA and NrfB passage into the periplasm

0.01 s ^–1

(7)

[*]^b

kt _{Nrf ,} pc

the rate constant for the NrfA and NrfB transport into the cytoplasm

10 s ^–1

(7)

k _{dis ,} NrfAB

the rate constant for the NrfAB dimer dissociation into subunits

10 s ^–1

(9)

K _{dis ,} NrfAB

the equilibrium dissociation constant for the NrfAB dimer

0.00004 mM

(9)

[18]

$k_{\mathit{dis},Nrf{A}_2{B}_2}$

the rate constant for the Nrf(AB)₂ dissociation into two NrfAB dimer proteins

10 s ^–1

(9)

$K_{\mathit{dis},Nrf{A}_2{B}_2}$

the equilibrium dissociation constant for the NrfA₂B₂ tetramer

0.004 mM

(9)

δ _peripl

the constant for the cytoplasmic volume to periplasmic volume ratio

6

(7)

[25]

d _U

parameters of the U generalized function that describes membrane potential relative value in relation to the added NO₂

3

(7)

[16]

δ

0.015

K _{pmf ,1}

0.115 mM

h _{pmf ,1}

2

K _{pmf ,2}

0.83 mM

h _{pmf ,2}

17

ω ₁, ω ₂ ^с

0^с

(7)

[*]^b

K _{pmf ,3} ^с

2.2

h _{pmf ,3} ^с

15

k _{d ,} NrfA

the rate constant for the NrfA monomer degradation in cytoplasm

9.6 10⁻⁶

sec ^–1

(11)

[29]

k _{d ,} NrfA

the rate constant for the NrfA monomer degradation in the periplasm

k _{d ,} NrfAB

the rate constant for the NrfAB degradation

$k_{d,Nrf{A}_2{B}_2}$

the rate constant for the NrfA₂B₂ degradation

$k_{\mathit{cat},Nrf{A}_2{B}_{2}u}$

the rate constant for the NrfA reductase turnover

700 s ^–1

(2)

[9]

$K_{\mathit{dis},Nrf{A}_2{B}_{2}u}$

the NrfA reductase Michaelis constant for nitrite

0.03 mM

[10]

δ _{nir, 1}

parameters of the m _nir generalized function that describes the nir operon activity changes in relation to the nitrite concentration established in the chemostat

7.86

(6)

[1], [35]

K _{nir ,1}

1.0 mM

h _{nir ,1}

2.0

δ _{nir, 2}

5.76

K _{nir ,2}

1.7 mM

h _{nir ,2}

8.3

$K_{\mathit{dis},Nir{B}_2}$

the equilibrium dissociation constant for the NirB₂ association reaction

0.002 mM

(10)

[*]^b

$K_{\mathit{dis},Nir{B}_{2}D}$

the equilibrium dissociation constant for the NirB₂D trimer association reaction

0.002 mM

(10)

$k_{\mathit{cat},Nir{B}_{2}Dw}$

the rate constant for the NirB enzyme catalytic turnover

1100.0 s ^–1

(5)

[*]^b

$K_{\mathit{dis},Nir{B}_{2}Dw}$

assumed to be equal the NirB reductase Michaelis constant

0.006 mM

[21]

$K_{\mathit{dis},Nir{C}_5}$

the rate constant for the NirC₅ dissociation

0.0475 mM

(8)

[*]^b

k _{cat ,} NirCin

the rate constant for nitrite import by the NirC protein

100 s ^–1

(3)

[*]^b

$K_{\mathit{dis},Nir{C}_{5}u}$

assumed to be equal the Michaelis constant for nitrite import by the NirC protein

1 mM

(3)

[31]

k _{cat ,} NirCout

the rate constant for the nitrite export by the NirC protein

1000 s⁻¹

(4)

[*]^b

$K_{\mathit{dis},Nir{C}_{5}w}$

assumed to be equal the Michaelis constant for the nitrite export by the NirC protein

1 mM

(4)

[31]

k _d,NirC

the rate constant for the NirC monomer degradation

0.0011 s⁻¹

(11)

[*]^b

k _d,NirC5

the rate constant for the NirC₅ pentamer degradation

0.00011 s⁻¹

k _d,NirB

the rate constant for the NirВ monomer degradation

0.00011 s⁻¹

k _d,NirD

the rate constant for the NirD monomer degradation

0.00011 s⁻¹

k _d,NirB2

the rate constant for the NirВ₂ dimer degradation

0.000011 s⁻¹

k _d,NirB2D

the rate constant for the NirВ₂D dimer degradation

0.000011 sec⁻¹

C

cell volume relative fraction in chemostat

0.0003

(2, 3)

[7], [29]