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Fig. 3 | BMC Microbiology

Fig. 3

From: Liver and blood cytokine microenvironment in HCV patients is associated to liver fibrosis score: a proinflammatory cytokine ensemble orchestrated by TNF and tuned by IL-10

Fig. 3

Hepatic Tissue Biomarkers in HCV patients according to the fibrosis score. a Frequency of intrahepatic T-cell subsets (CD4+, CD8+, Treg and CD4+/CD8+ ratio) in HCV patients () categorized into subgroups referred as F1-2 () and F3-4 (). b Levels of tissue cytokines (IL-6, TNF, IL-2, IFN-γ, IL-4, IL-10 and IL-17) secreted by mononuclear cells cultured in vitro for 12 h in RPMI (1x106cells/mL) at 37 °C, 5 % CO2. Data are expressed as scattering of individual percentage of intra-hepatic T-cell subsets within gated lymphocytes or tissue for cytokine concentration (MFI). The median values of each biomarker was calculated for the HCV group and used as a cut off to segregate subjects presenting high (continuous lined rectangle) or low (dashed lined rectangle) biomarker levels. The Chi-square test was used to compare the frequency of subjects presenting high or low biomarker levels between the HCV subgroups (F1-2 versus F3-4). The frequencies of subjects presenting high or low biomarker levels in the F1-2 versus F3-4 subgroups are provided in the figure. In all cases, significant differences at P < 0.05 were found between F1-2 versus F3-4

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