Fig. 1

Primary sequence analysis. An “*” (asterisk) indicates positions that have a single, fully conserved residue; A “:” (colon) indicates conservation between groups with strongly similar properties - scoring > 0.5 in the Gonnet PAM 250 matrix; A “.” (period) indicates conservation between groups of weakly similar properties - scoring = < 0.5 in the Gonnet PAM 250 matrix. The code of colors according to their physicochemical properties are as follows: red, small and hydrophobic (AVFPMILW); blue, acidic (DE); magenta, basic (RK); and green, (STYHCNGQ)