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Table 1 Mean bacterial count recovered from the in vitro catheter model at different time-points

From: In vitro efficacy of daptomycin and teicoplanin combined with ethanol, clarithromycin or gentamicin as catheter lock solutions

  1018 1022 1076 1098
Atimicrobial regimen t = 0 t = 72 t = 96 t = 0 t = 72 t = 96 t = 0 t = 72 t = 96 t = 0 t = 72 t = 96
Control 8,017 9,02 8,97 7,92 8,67 9,02 7,82 8,45 8,83 7,83 9,12 9,16
Teicoplanin 8,02 4,45* 6,72 7,09 4,03* 6,57 7,04 3,94* 7,44 7,89 3,84* 6,32
Teicoplanin + gentamycin 8,03 5,12* 7,01 7,43 4,5* 6,59 7,52 3,22* 6,67 7,78 2,64* 5,29
Teicoplanin + ethanol 7,94 1* 4,45* 7,85 1* 2,3* 7,27 1* 3,43 7,93 1* 4,02*
Teicoplanin + clarithromycin 7,95 1,89* 4,23* 7,86 1,23* 4,32* 7,29 1* 3,04 7,82 1,78* 5,38
Daptomycin 8,24 2,87*, ** 4,89* 7,33 1*, ** 3,77* 7,32 2,54* 5,48 7,82 3,62* 5,92
Daptomycin + gentamycin 8,12 2,03*, ** 5,67 7,51 3,69* 6,46 7,12 2,12* 4,92* 8,01 1,96* 5,01
Daptomycin + ethanol 7,98 1* 1*, ** 7,79 1* 1*, ** 7,027 1* 1*, ** 8,01 1* 1*, **
Daptomycin + clarithromycin 8,34 1,45* 4,67* 7,95 1* 1*, ** 7,57 1* 1*, ** 7,83 1* 3,84*
  1. Data expressed as Log10CFU/mL
  2. T = 0: baseline. T = 72: end of antibiotic lock therapy. T = 96 h: after reincubation with sterile fresh media
  3. *p < 0.05 versus control
  4. **p < 0.05 vs teicoplanin (alone or in each combination compared against the same combination)