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Table 1 Mean bacterial count recovered from the in vitro catheter model at different time-points

From: In vitro efficacy of daptomycin and teicoplanin combined with ethanol, clarithromycin or gentamicin as catheter lock solutions

 

1018

1022

1076

1098

Atimicrobial regimen

t = 0

t = 72

t = 96

t = 0

t = 72

t = 96

t = 0

t = 72

t = 96

t = 0

t = 72

t = 96

Control

8,017

9,02

8,97

7,92

8,67

9,02

7,82

8,45

8,83

7,83

9,12

9,16

Teicoplanin

8,02

4,45*

6,72

7,09

4,03*

6,57

7,04

3,94*

7,44

7,89

3,84*

6,32

Teicoplanin + gentamycin

8,03

5,12*

7,01

7,43

4,5*

6,59

7,52

3,22*

6,67

7,78

2,64*

5,29

Teicoplanin + ethanol

7,94

1*

4,45*

7,85

1*

2,3*

7,27

1*

3,43

7,93

1*

4,02*

Teicoplanin + clarithromycin

7,95

1,89*

4,23*

7,86

1,23*

4,32*

7,29

1*

3,04

7,82

1,78*

5,38

Daptomycin

8,24

2,87*, **

4,89*

7,33

1*, **

3,77*

7,32

2,54*

5,48

7,82

3,62*

5,92

Daptomycin + gentamycin

8,12

2,03*, **

5,67

7,51

3,69*

6,46

7,12

2,12*

4,92*

8,01

1,96*

5,01

Daptomycin + ethanol

7,98

1*

1*, **

7,79

1*

1*, **

7,027

1*

1*, **

8,01

1*

1*, **

Daptomycin + clarithromycin

8,34

1,45*

4,67*

7,95

1*

1*, **

7,57

1*

1*, **

7,83

1*

3,84*

  1. Data expressed as Log10CFU/mL
  2. T = 0: baseline. T = 72: end of antibiotic lock therapy. T = 96 h: after reincubation with sterile fresh media
  3. *p < 0.05 versus control
  4. **p < 0.05 vs teicoplanin (alone or in each combination compared against the same combination)