Skip to main content

Table 2 Proteins identified in the secretome of C. neoformans collected at 96 hpi from cells grown in Pka1-repressed (glucose-containing medium) conditions

From: Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

GO categoriesa Accession number Protein name Fold changeb Std. Dev.
Carbohydrate catabolic process
  CNAG_02189 α-Amylase 0.777 0.019
GTP catabolic process
  CNAG_06125 Translation elongation factor 1 α 2.062 2.181
Carbohydrate metabolic process
  CNAG_02860 Endo-1,3(4)-β-glucanase 0.947 0.583
  CNAG_06501 1,3-β-glucanosyltransferase 0.968 0.100
  CNAG_05799 Chitin deacetylase 1.439 0.775
  CNAG_06291 Deacetylase 1.464 0.778
  CNAG_01239 Chitin deacetylase 2.014 0.584
Cellular carbohydrate metabolic process
  CNAG_03225 Malate dehydrogenase 0.472 0.546
Pentose-phosphate pathway
  CNAG_07561 Phosphogluconate dehydrogenase >10 >10
Protein ubiquitination
  CNAG_01920 Polyubiquitin 1.261 0.396
ATP hydrolysis coupled proton transport
  CNAG_05918 F0F1 ATP synthase subunit β 0.451 0.249
  CNAG_05750 ATPase α subunit 0.604 0.387
Transmembrane transport
  CNAG_06101 Eukaryotic ADP/ATP carrier 7.524 9.753
Methionine biosynthetic process
  CNAG_01890 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase 0.778 0.327
Dephosphorylation
  CNAG_02944 Acid phosphatase 1.862 0.083
Glycolysis
  CNAG_03072 Phosphopyruvate hydratase 3.093 3.377
Oxidation-reduction process
  CNAG_01019 Cu/Zn superoxide dismutase 0.302 0.161
  CNAG_03465 Laccase 0.718 0.668
Proteolysis
  CNAG_00919 Carboxypeptidase D 4.664 5.261
Response to stress
  CNAG_01727 Hsc70-4 1.883 2.094
Translation
  CNAG_06095 Ribosomal protein L13 0.147 0.057
Unknown/Unclassified
  CNAG_01653 Cytokine-inducing glycoprotein 0.134 0.158
  CNAG_00407 Glyoxal oxidase 0.719 0.230
  CNAG_04291 Glycosyl-hydrolase 0.583 0.287
  CNAG_02030 Glyoxal oxidase 0.513 0.109
  CNAG_06267 Rds1 protein 3.409 0.106
Hypothetical
  CNAG_05312 Conserved hypothetical protein 0.341 0.100
  CNAG_03007 Conserved hypothetical protein 0.518 0.649
  CNAG_01562 Conserved hypothetical protein 0.942 0.194
  CNAG_05893 Conserved hypothetical protein 0.991 0.487
  CNAG_01047 Conserved hypothetical protein 6.714 6.494
  CNAG_00588 Conserved hypothetical protein >10 >10
  CNAG_03223 Conserved hypothetical protein >10 >10
  CNAG_00586 Conserved hypothetical protein >10 >10
  1. aProteins were categorized based on GO terms associated with their biological classification
  2. bFold change is reported as the average quantification for P GAL7 ::PKA1 vs. WT, ± standard deviation