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Table 1 Proteins identified in the secretome of C. neoformans collected at 16, 48, 72, and 120 hpi grown in Pka1-repressed (glucose-containing medium) and Pka1-induced (galactose-containing medium) conditions

From: Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

GO categoriesa Accession number Protein Name   Fold changeb* Std. Dev.
Time point Pka1-repression Pka1-induction Pka1-repression Pka1-induction
Carbohydrate catabolic process      
  CNAG_02189 α-Amylase 16 hpi 0.298 1.096 0.314 1.270
GTP catabolic process       
  CNAG_06125 Translation elongation factor 1 α 16 hpi 0.135 0.379 0.145 0.517
Carbohydrate metabolic process      
  CNAG_01239 Chitin deacetylase 16 hpi 0.906 1.350 0.310 0.515
  CNAG_04245 Chitinase 16 hpi 0.448 0.286 0.007 0.296
    48 hpi 0.826 0.603 1.019 0.017
  CNAG_06501 1,3-β-glucanosyltransferase 16 hpi 0.573 0.896 0.383 0.169
Transmembrane transport       
  CNAG_02974 Voltage-dependent ion-selective channel 16 hpi 0.223 0.466 0.089 0.645
Oxidation-reduction process       
  CNAG_03465 Laccase 16 hpi 0.637 0.870 0.651 1.038
Unknown/Unclassified       
  CNAG_02030 Glyoxal oxidase 16 hpi 0.278 0.600 0.324 0.672
    48 hpi 0.242 0.350 0.063 0.144
  CNAG_06267 Rds1 protein 16 hpi 0.336 0.756 0.303 0.222
    120 hpi 0.860 5.106 0.444 4.588
  CNAG_00776 Immunoreactive mannoprotein MP88 16 hpi 0.627 0.994 0.214 1.193
  CNAG_02864 Predicted protein 16 hpi 0.346 0.259 0.056 0.183
  CNAG_04753 Lactonohydrolase 16 hpi 1.031 0.751 0.631 0.413
    48 hpi 1.250 1.055 0.996 0.546
Hypothetical       
  CNAG_00587 Hypothetical protein 16 hpi 1.275 1.620 0.018 0.371
  CNAG_01047 Hypothetical protein 16 hpi 0.279 0.471 0.070 0.272
    72 hpi 0.928 0.719 1.034 0.432
  CNAG_03492 Hypothetical protein 16 hpi 0.506 0.799 0.400 0.030
    72 hpi 0.640 1.180 0.199 0.431
  CNAG_05893 Hypothetical protein 48 hpi 1.609 1.676 1.380 1.639
    120 hpi 1.641 1.413 0.953 0.348
  1. aProteins were categorized based on GO terms associated with their biological classification
  2. bFold change is reported as the average quantification for P GAL7 ::PKA1 vs. WT, ± standard deviation
  3. *Statistical analysis was performed using a Student’s t-test between the conditions. None of the comparisons resulted in a significant difference in protein abundance (p-value > 0.05)