Fig. 4

Susceptibility of C57BL/6 mice to infection with DENV. The animals were inoculated with macrophages infected in vitro with D2/BR/RP/RMB/2009 (n = 5) (a and b) and the D3/BR/SL3/02 (n = 5) (c and d) isolates, and Mochizuki strain (n = 5) (E and F), which were previously incubated with heterologous antibodies (a, c and e) or PBS (b, d and f). The infection was confirmed by detection of the virus genome by real-time RT-PCR in serum and organs. Data represent the mean values ± SD. The results are representative of two similar and independent experiments