TY - JOUR AU - Wickramasinghe, Saumya AU - Pacheco, Alline R. AU - Lemay, Danielle G. AU - Mills, David A. PY - 2015 DA - 2015/08/25 TI - Bifidobacteria grown on human milk oligosaccharides downregulate the expression of inflammation-related genes in Caco-2 cells JO - BMC Microbiology SP - 172 VL - 15 IS - 1 AB - Breastfed human infants are predominantly colonized by bifidobacteria that thrive on human milk oligosaccharides (HMO). Two predominant species of bifidobacteria in infant feces are Bifidobacterium breve (B. breve) and Bifidobacterium longum subsp. infantis (B. infantis), both of which include avid HMO-consumer strains. Our laboratory has previously shown that B. infantis, when grown on HMO, increases adhesion to intestinal cells and increases the expression of the anti-inflammatory cytokine interleukin-10. The purpose of the current study was to investigate the effects of carbon source—glucose, lactose, or HMO—on the ability of B. breve and B. infantis to adhere to and affect the transcription of intestinal epithelial cells on a genome-wide basis. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-015-0508-3 DO - 10.1186/s12866-015-0508-3 ID - Wickramasinghe2015 ER -