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Fig. 1 | BMC Microbiology

Fig. 1

From: Representing virus-host interactions and other multi-organism processes in the Gene Ontology

Fig. 1

Nuclear egress represented in ViralZone and the Gene Ontology. Viral capsids assembled in the nucleus can migrate to the cytoplasm by utilizing an unusual export pathway termed ‘nuclear egress’. In this process, the viral capsid is delivered into the perinuclear space, producing a vesicular intermediate after fission. After fusion with the outer nuclear membrane, the naked capsid is released into the cytosol. The corresponding GO term ‘exit of virus from host cell nucleus by nuclear egress’ (GO:0046802) is mapped to ViralZone entry 1952. The sub-processes are described by GO terms ‘nuclear capsid assembly’ (GO:0039708) corresponding to ViralZone entry 1516, ‘viral budding from nuclear membrane’ (GO:0046765), ‘fusion of viral membrane with host outer nuclear membrane’ (GO:0039700) and ‘viral capsid secondary envelopment’ (GO:0046745)

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