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Fig. 3 | BMC Microbiology

Fig. 3

From: Broad protection with an inactivated vaccine against primary-isolated lethal enterovirus 71 infection in newborn mice

Fig. 3

Pathological analysis of infected newborn mice after intracerebral challenge with a lethal dose (106.5 CCID50/ml) of EV-A71CC063. One-day-old ICR mice were intracerebrally inoculated with EV-A71CC063 (106.5 CCID50/ml) or medium (mock control). Representative images from the hind-limb muscle, spine muscle, cardiac muscle, and lung tissue at 6 days post-infection are shown. Infected mice (clinical grades 4-5) exhibited severe necrosis in the hind-limb muscle (b) and spinal skeletal muscle (d), but no obvious histological changes in cardiac muscle (f) or lung tissue (h) by HE staining. The results for non-infected mice were used as a control (a, c, e, and g). Magnification, 400 ×

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