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Table 4 Invasive Neisseria meningitidis from Québec, Canada in 2009-2013: predicted vaccine coverage based on at least one antigen showing an exact match to the 4CMenB vaccine components or with Novartis variant 1 factor H binding protein (fHbp)/Neisseria adhesin A (NadA) peptides belonging to variants 1 to 3

From: Characterization of invasive Neisseria meningitidis strains from Québec, Canada, during a period of increased serogroup B disease, 2009-2013: phenotyping and genotyping with special emphasis on the non-carbohydrate protein vaccine targets

  Predicted coverage based on exact match to 4CMenB componentsa
CC ST Serogroup # of isolates fHbpb NHBA NadA-2/3c PorA
ST-41/44 ST-41 B 1 Possibly, 4 Yes No Yes
  ST-154 B 1 Possibly, 4 Yes No Yes
  ST-41 B 1 Possibly, 4 Yes No No
  ST-1194 B 1 Possibly, 4 Yes No No
  ST-8052 B 1 Possibly, 14 Yes No No
  ST-10619 B 1 Possibly, 100 Yes No No
ST-32 CC ST-32 B 2 Yes, 1 Unknown No No
ST-174 CC ST-1466 Y 1 No Unknown 8 No
Additional coverage based on strains predicted to express NadA-1,2/3 and/or Novartis variant 1 fHbp peptides
ST-269 CC ST-269 B 143 Possibly, 15 Unknown No No
  ST-1986 B 4 Possibly, 15 Unknown No No
  ST-5494 B 3 Possibly, 15 Unknown No No
  ST-8767 B 1 Possibly, 15 Unknown No No
  ST-8880 B 1 Possibly, 15 Unknown No No
  ST-2738 B 1 Possibly, 249 Unknown No No
ST-32 CC ST-33 B 1 Possibly, 144 Unknown 85 No
  ST-2726 B 2 No Unknown 1 No
ST-35 CC ST-278 B 1 Possibly, 4 Unknown No No
ST-1157 CC ST-1157 B 2 Possibly, 13 Unknown No No
ST-60 CC ST-10587 B 1 Possibly, 13 Unknown No No
ST-254 CC ST-10332 B 1 Possibly, 13 Unknown No No
Not assignedd ST-336 B 1 No Unknown 3 No
  ST-7655 B 1 Possibly, 13 Unknown No No
  ST-7704 B 1 Possibly, 110 Unknown No No
  ST-9248 B 1 Possibly, 12 Unknown No No
ST-11 CC ST-11 C 2 No Unknown 3 No
  ST-11 C 1 No Unknown 2 No
  ST-11 C 1 Possibly, 12 Unknown No No
  ST-11 C 1 Possibly, 129 Unknown No No
  ST-11 C 1 Possibly, 218 Unknown No No
ST-167 CC ST-6171 Y 1 Possibly, 278 Unknown No No
  1. a4CMenB vaccine components include: factor H binding protein (fHbp) peptide 1; Neisseria Heparin Binding Antigen (NHBA) peptide 2; Neisseria adhesion A (NadA)-2/3 peptide 8; and outer membrane protein porin A (PorA) P1.4
  2. bNovartis variant 1 peptides were indicated by their peptide number possibly covered by the vaccine; whereas variants 2/3 peptides were labelled as No to indicate no match or not covered by the 4CMenB vaccine
  3. cNadA variant 1-3 peptides were indicated by their peptide number; whereas No was used to indicate absence of the nadA gene
  4. dNot assigned to any known clonal complex according to the current Neisseria MLST website (http://pubmlst.org/neisseria/)