Table 3 AA’s and its combinations associated with high and low pathogenicity in all the proteins

HA

D-43^HA1, A-83^HA1, I-71^HA1

-

S-43^HA1, D-83^HA1, S-107^HA1, N-138^HA1, D-309^HA1, V-302^HA1, A-7^sp, I-6^sp, D-275^HA1, N-195^HA1, S-240^HA1, R-3^SP, S-194^HA1

-

NA

N-369, G-386, T-288, H-100, D-269, H-41

-

N-400, K-38, V-192, P-90, I-73, I-262, L-255, M-24, S-14, E-41, S-269, K-187, T-434, E-74, S-43

-

NS1

N-48, L-207, N-212

R-59 & N-212,

M-27

P-208 & K-212,

F-22 & N-48

S-82 & R-113 & D-166,

F-22 & S-82 & T-89 & R-113,

P55 = E & P73 = S & P82 = S & P89 = T & P113 = R

S-48 & S-73 & S-82 & D-166,

S-48 & S-82 & D-166,

S-82 & A-107 & R-113,

S-73 & S-82 & R-113,

S-82 & R-113,

S-82 & K-212

NS2

A-22, A-115, V-14

V-6 & I-60

-

V-49 & S-60

M1

A-166, N-232, N-224, K-27, I-168

T-121 & I-168

V-166, R-101

V-166 & D-232

M2

E-14

-

-

G-14 & E-66,

G-14 & I-28,

G-14 & K-18,

I-28 & S-82,

K-18 & I-28

NP

S-34

N-377 & N-482,

N-450

K-77 & V-353 & S-377

S-34 & N-377,

S-34 & N-482,

R-77 & N-482,

R-77 & N-377,

A-373 & S-450,

A-373 & N-377

PA

T-129, S-58

-

-

-

PB1

I-149, V-14, L-384

I-113 & I-149,

-

A-14 & V-113 & G-154 & S-3

V-14 & I-113,

I-113 & K-386,

T-59 & 113-I & K-215,

I-113 & K215

PB2

M-64, T-339

-

I-478

M-64 & I-478

PB1-F2

Y-57, P-48

-

Q-48, D-50

-