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Table 3 AA’s and its combinations associated with high and low pathogenicity in all the proteins

From: A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins

  Association to high pathogenicity Association to low pathogenicity
  Singular residues Combination of residues Singular residues Combination of residues
HA D-43HA1, A-83HA1, I-71HA1 - S-43HA1, D-83HA1, S-107HA1, N-138HA1, D-309HA1, V-302HA1, A-7sp, I-6sp, D-275HA1, N-195HA1, S-240HA1, R-3SP, S-194HA1 -
NA N-369, G-386, T-288, H-100, D-269, H-41 - N-400, K-38, V-192, P-90, I-73, I-262, L-255, M-24, S-14, E-41, S-269, K-187, T-434, E-74, S-43 -
NS1 N-48, L-207, N-212 R-59 & N-212, M-27 P-208 & K-212,
F-22 & N-48 S-82 & R-113 & D-166,
F-22 & S-82 & T-89 & R-113,
P55 = E & P73 = S & P82 = S & P89 = T & P113 = R
S-48 & S-73 & S-82 & D-166,
S-48 & S-82 & D-166,
S-82 & A-107 & R-113,
S-73 & S-82 & R-113,
S-82 & R-113,
S-82 & K-212
NS2 A-22, A-115, V-14 V-6 & I-60 - V-49 & S-60
M1 A-166, N-232, N-224, K-27, I-168 T-121 & I-168 V-166, R-101 V-166 & D-232
M2 E-14 - - G-14 & E-66,
G-14 & I-28,
G-14 & K-18,
I-28 & S-82,
K-18 & I-28
NP S-34 N-377 & N-482, N-450 K-77 & V-353 & S-377
S-34 & N-377,
S-34 & N-482,
R-77 & N-482,
R-77 & N-377,
A-373 & S-450,
A-373 & N-377
PA T-129, S-58 - - -
PB1 I-149, V-14, L-384 I-113 & I-149, - A-14 & V-113 & G-154 & S-3
V-14 & I-113,
I-113 & K-386,
T-59 & 113-I & K-215,
I-113 & K215
PB2 M-64, T-339 - I-478 M-64 & I-478
PB1-F2 Y-57, P-48 - Q-48, D-50 -
  1. AA’s for the HA protein are shown to be either of HA1, HA2 or Signal Peptide (SP). AA’s for the NA protein shown are numbered according to the whole length sequences i.e. the sequences without the stalk deletion