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Fig. 1 | BMC Microbiology

Fig. 1

From: Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family

Fig. 1

Gene cluster organization and precursor peptide sequences of SLS-like cytolysins, and post-translational modification scheme. a Lettering corresponds to the SLS operon “sag” genes. The proposed function of each gene is color-coded according to the legend. A representative is shown, as in some cases, organization varies among strains and/or not all strains of a species possess the cluster. b Heterocyclizable residues (Cys, Ser, Thr) are shown in blue. The predicted leader cleavage sites are indicated with carets. abioactivity of “clostridiolysin S” shown from C. sporogenes [17] and upon heterologous expression in S. pyogenes ΔsagA [7] bbioactivity of “listeriolysin S” shown from native producers [19, 18], but neither the precursor peptide nor core peptide fused to SagA leader were cytolytic upon heterologous expression in S. pyogenes ΔsagA [7]. cbioactivity of putative cytolysin not yet shown from a native producer, but core peptide fused to SagA leader cytolytic upon heterologous expression in S. pyogenes ΔsagA [7]. c Azole heterocycles are installed on a TOMM precursor peptide by the successive action of a cyclodehydratase (C and D proteins) and dehydrogenase (B protein). X = S or O; R = H or CH3

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