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Table 1 In vitro antibiotic susceptibility of planktonic and biofilm S. pseudintermedius strain DSM 25713 cells. MIC, Minimum Inhibitory Concentration; MBC, Minimum Bactericidal Concentration; MBEC50 and MBEC90, Minimum Concentrations Eradicating respectively 50 % and 90 % of Biofilm viability, compared to untreated controls (100 % viability). Assays were performed in triplicate and repeated on two different occasions (n = 6). Values are mg/L

From: New insights in Staphylococcus pseudintermedius pathogenicity: antibiotic-resistant biofilm formation by a human wound-associated strain

Antibiotics

Planktonic cells

Biofilm cells

C max a

MIC

MBC

MBEC50

MBEC90

Chloramphenicol

32

256

128

4,096

16.9 [49]

Gentamicin

0.5

0.5

32

32

5-12 [50]

Cefoxitin

16

32

16

1,024

20 [51]

Linezolid

4

32

4

1,024

21.2 [52]

Rifampicin

0.03

0.5

0.03

0.06

10 [53]

Tigecycline

0.5

8

0.5

64

0.25-2.8 [54]

Tetracycline

0.5

8

0.5

64

2 [55]

Vancomycin

2

2

16

32

25 [56]

  1. aMaximum concentration of drug in serum; references are shown in parentheses