Table 1 Agreement between the results of the European Committee for Antimicrobial Susceptibility Testing and Clinical Laboratory Standards Institute broth microdilution methods for anidulafungin, caspofungin, and micafungin
Isolates (No.) | Antifungal drug | BMD method | MIC (μg mL−1) | No. (%) S | No. (%) I | No. (%) R | EA (%) | CA (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
Range | Mode | GM | MIC90 | ||||||||
C. albicans (251) | Anidulafungin | CLSI | ≤0.008–2 | 0.12 | 0.03 | 0.12 | 246(98) | 2(0.8) | 3(1.2) | 90 | 99 |
EUCAST | ≤0.008–2 | 0.03 | 0.02 | 0.03 | 247(98.4) | NA | 4(1.6) | ||||
Micafungin | CLSI | ≤0.008–1 | 0.008 | 0.01 | 0.12 | 241(96) | 7(2.8) | 3(1.2) | 92 | 98 | |
EUCAST | ≤0.008–0.5 | 0.016 | 0.01 | 0.016 | 244(97.2) | NA | 7(2.8) | ||||
Caspofungin | CLSI | ≤0.008–4 | 0.5 | 0.17 | 0.5 | 180(71.7) | 63(25.1) | 8(3.2) | 87 | NA | |
EUCAST | ≤0.008–2 | 0.016 | 0.13 | 0.5 | − | − | − | ||||
C. parapsilosis complex (224) | Anidulafungin | CLSI | 0.03–2 | 1 | 1.14 | 2 | 224(100) | 0 | 0 | 96 | 100 |
EUCAST | 0.06–2 | 2 | 1.78 | 2 | 0 | 224(100) | 0 | ||||
Micafungin | CLSI | 0.016–2 | 1 | 0.96 | 2 | 224(100) | 0 | 0 | 95 | 100 | |
EUCAST | 0.016–2 | 2 | 1.62 | 2 | 0 | 224(100) | 0 | ||||
Caspofungin | CLSI | 0.25–8 | 2 | 1.62 | 2 | 217(96.9) | 6(2.7) | 1(0.4) | 98 | NA | |
EUCAST | 0.06–8 | 2 | 1.82 | 2 | − | − | − | ||||
C. tropicalis (46) | Anidulafungin | CLSI | ≤0.008–1 | 0.12 | 0.09 | 0.25 | 45(97.8) | 0 | 1(2.2) | 91 | 93 |
EUCAST | ≤0.008–0.25 | 0.06 | 0.05 | 0.06 | 42(91.3) | NA | 4(8.7) | ||||
Micafungin | CLSI | ≤0.008–1 | 0.12 | 0.07 | 0.5 | 37(80.4) | (17.4) | 1(2.2) | 91 | NA | |
EUCAST | 0.016–2 | 0.06 | 0.11 | 0.5 | − | − | − | ||||
Caspofungin | CLSI | ≤0.008–2 | 0.12 | 0.12 | 1 | 34(74) | 6(13) | 6(13) | 89 | NA | |
EUCAST | ≤0.008–2 | 0.06 | 0.11 | 1 | − | − | − | ||||
C. glabrata complex (37) | Anidulafungin | CLSI | ≤0.008–4 | 0.25 | 0.13 | 0.25 | 24(64.9) | 12(32.4) | 1(2.7) | 72 | 89 |
EUCAST | ≤0.008–2 | 0.03 | 0.06 | 0.12 | 32(86.5) | NA | 5(13.5) | ||||
Micafungin | CLSI | ≤0.008–1 | 0.06 | 0.06 | 0.12 | 28(75.7) | 4(10.8) | 5(13.5) | 83 | 95 | |
EUCAST | ≤0.008–2 | 0.03 | 0.05 | 0.12 | 30(81.1) | NA | 7(18.9) | ||||
Caspofungin | CLSI | ≤0.008–4 | 0.12 | 0.18 | 1 | 21(56.8) | 10(27) | 6(16.2) | 80 | NA | |
EUCAST | ≤0.008–2 | 0.06 | 0.17 | 2 | − | − | − | ||||
C. guilliermondii (15) | Anidulafungin | CLSI | 1–2 | 1 | 1.45 | 2 | 14(93.3) | 1(6.7) | 0 | 100 | NA |
EUCAST | 1–2 | 2 | 1.91 | 2 | − | − | − | ||||
Micafungin | CLSI | 0.5–2 | 2 | 1.45 | 2 | 15(100) | 0 | 0 | 100 | NA | |
EUCAST | 0.5–2 | 2 | 1.52 | 2 | − | − | − | ||||
Caspofungin | CLSI | 0.12–4 | 2 | 1.74 | 2 | 14(93.3) | 1(6.7) | 0 | 93 | NA | |
EUCAST | 1–2 | 2 | 1.74 | 2 | − | − | − | ||||
C. krusei (11) | Anidulafungin | CLSI | 0.12–0.5 | 0.12 | 0.14 | 0.12 | 10(90.9) | 1(9) | 0 | 90 | 91 |
EUCAST | 0.06–0.12 | 0.06 | 0.06 | 0.06 | 10(90.9) | NA | 1(9.1) | ||||
Micafungin | CLSI | 0.06–0.5 | 0.12 | 0.13 | 0.12 | 11(100) | 0 | 0 | 100 | NA | |
EUCAST | 0.03–0.5 | 0.06 | 0.08 | 0.25 | − | − | − | ||||
Caspofungin | CLSI | 0.12–2 | 0.5 | 0.44 | 2 | 6(54.5) | 4(36.4) | 1(9.1) | 90 | NA | |
EUCAST | 0.06–2 | 0.12 | 0.23 | 1 | − | − | − | ||||