Sera
|
SBA titers
|
|---|
α-PilA-AL(OH)3 | 341 ± 147 |
α-HtrA-AL(OH)3 | 853 ± 295 |
α-PE-AL(OH)3 | 512 |
α-OMP26-AL(OH)3 | 192 ± 90 |
α-PD-AL(OH)3 | 853 ± 295 |
α-P6-AL(OH)3 | 213 ± 74 |
α-AL(OH)3 | <4 |
α-176
| 8192 |
α-NHBA-AL(OH)3 | <16 |
pre-immune sera
| <4 |
α-PBS
| <4 |
- Bactericidal titers obtained using sera against specific antigens are reported. Titers are expressed as the reciprocal of the serum dilution necessary to obtain >50% bacterial killing. Experiments were performed three times and average titers is reported. Serum against NTHi was used as positive control. Sera from non-immunized mice (pre-immune sera), mice immunized with PBS alone, mice immunized with adjuvant alone (AL(OH)3), mice immunized with an adjuvanted unrelated antigen (NHBA from N. meningitidis) were used as negative controls. Data are means and standard errors of the means from 3 separate experiments.
