Cell death pathways hypothesized to be involved in IL-32 control of
infection in macrophages. Macrophages can undergo apoptosis through various mechanisms including those mediated by caspase-3, caspase-1, cathepsins, and AIF. While all four pathways contribute to macrophage control of MTB infection, caspase-3, caspase-1, and cathepsins, but not AIF, mediate the anti-MTB effects of IL-32γ in macrophages. Fragmented DNA is used to depict the various forms of programmed cell death. Both extrinsic and intrinsic pathways of classical apoptosis are shown in the caspase-3-dependent apoptosis. MTB are illustrated by red bacilli in phagosomes.