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Table 2 Antimicrobial susceptibility profiles and genetic resistance markers of linezolid-resistant Staphylococcus and Enterococcus isolates

From: Mechanisms of linezolid resistance in staphylococci and enterococci isolated from two teaching hospitals in Shanghai, China

Strain ID

Source

ST

MIC ( μg/ml)

 

Genetic resistance markers

   

LZD

VAN

TEC

OXA

FOX

ERY

CLI

CHL

TET

CIP

PEN

AMP

GNH

SXT

23S rRNA mutation (percentage of clones with mutation)

cfr

L3

L4

L22

S. capitis

                   

HS09-206

blood

N/D

8

1

0.25

>256

R

>256

>256

32

4

64

64

N/D

N/D

2/38

C2131T (43.3%)

-

-

-

-

G2603T (70.0%)

HS09-17

blood

N/D

16

1

0.25

256

R

>256

256

32

4

64

32

N/D

N/D

2/38

C2131T (46.7%)

-

-

-

-

G2603T (83.3%)

HS10-204

blood

N/D

32

1

0.5

>256

R

>256

>256

128

4

64

64

N/D

N/D

4/76

C2131T (36.7%)

-

-

-

-

G2603T (66.7%)

HS10-24

blood

N/D

64

1

0.25

256

R

>256

>256

32

4

64

32

N/D

N/D

8/152

C2131T (53.3%)

-

-

-

-

G2603T (80.0%)

HS11-203

blood

N/D

256

1

0.25

>256

R

>256

>256

128

4

64

64

N/D

N/D

2/38

C2131T (60.0%)

+

-

-

-

G2603T (80.0%)

HS11-44

blood

N/D

256

1

0.25

>256

R

>256

256

64

4

64

32

N/D

N/D

2/38

C2131T (53.3%)

+

-

-

-

G2603T (80.0%)

HS12-49

blood

N/D

256

1

0.5

>256

R

>256

>256

128

4

64

32

N/D

N/D

4/76

C2131T (70.0%)

+

-

-

-

G2603T (70.0%)

HS12-201

blood

N/D

512

1

0.25

>256

R

>256

>256

128

4

64

64

N/D

N/D

4/76

C2131T (60.0%)

+

-

C316T(Arg106 Cys)

-

G2603T (100%)

HS12-51

blood

N/D

128

1

0.5

256

R

>256

256

32

4

64

64

N/D

N/D

2/38

C2131T (36.7%)

+

-

-

-

G2603T (63.3%)

HS12-53

blood

N/D

512

1

0.25

>256

R

>256

256

128

4

64

32

N/D

N/D

8/152

C2131T (60.0%)

+

-

-

-

G2603T (80.0%)

HS12-55

blood

N/D

512

1

0.25

>256

R

>256

>256

128

4

64

32

N/D

N/D

4/76

C2131T (50.0%)

+

-

C316T(Arg106 Cys)

-

G2603T (86.7%)

HS12-58

blood

N/D

512

1

0.25

>256

R

>256

>256

64

2

32

8

N/D

N/D

4/76

C2131T (60.0%)

G2603T (100%)

+

-

-

-

HS13-60

blood

N/D

256

1

0.5

>256

R

>256

>256

64

4

64

64

N/D

N/D

4/76

C2131T (60.0%)

+

-

-

-

G2603T (76.7%)

HS13-207

blood

N/D

32

1

0.25

>256

R

>256

>256

32

4

64

32

N/D

N/D

8/152

C2131T (83.3%)

-

-

-

-

G2603T (100%)

S. aureus

                   

HS09-205

sputum

88

8

1

0.5

<0.25

S

>256

>256

32

0.5

64

32

N/D

N/D

0.12/2.37

-

-

-

-

-

HS11-202

sputum

239

16

1

1

>256

R

>256

>256

32

4

128

128

N/D

N/D

0.25/4.75

-

-

C389G(Ala130Gly)

-

-

HS12-56

sputum

5

32

1

1

>256

R

>256

>256

32

8

128

8

N/D

N/D

0.12/2.37

-

+

-

-

-

E. faecalis

                   

HS10-311

urine

16

4

1

0.12

N/D

N/D

>256

N/D

32

128

64

2

<0.5

R

N/D

-

-

-

-

-

HS11-304

blood

16

4

1

0.5

N/D

N/D

>256

N/D

32

64

16

2

<0.5

S

N/D

-

-

-

-

-

HS11-305

urine

476

4

1

0.25

N/D

N/D

>256

N/D

32

128

16

4

<0.5

R

N/D

-

-

-

-

-

HS11-307

urine

4

4

2

0.12

N/D

N/D

>256

N/D

32

1

64

0.5

<0.5

R

N/D

-

-

-

-

-

HS12-309

urine

69

8

2

0.12

N/D

N/D

>256

N/D

32

64

64

0.5

<0.5

S

N/D

-

-

-

-

-

HS12-308

urine

480

8

1

0.25

N/D

N/D

>256

N/D

32

32

64

4

<0.5

S

N/D

-

-

-

-

-

HS12-310

wound

300

8

1

0.25

N/D

N/D

>256

N/D

32

64

64

2

4

S

N/D

-

-

-

-

-

HS13-301

urine

476

8

1

0.25

N/D

N/D

>256

N/D

64

128

64

2

<0.5

S

N/D

-

-

-

-

-

HS13-302

bile

27

8

0.5

0.125

N/D

N/D

>256

N/D

32

128

64

2

<0.5

R

N/D

-

-

-

-

-

HS13-303

urine

480

8

1

0.125

N/D

N/D

>256

N/D

32

64

16

0.5

<0.5

S

N/D

-

-

-

-

-

RJ13 -314

urine

69

8

1

0.12

N/D

N/D

>256

N/D

32

64

16

1

<0.5

S

N/D

-

-

-

-

-

RJ13 -315

urine

4

8

1

0.25

N/D

N/D

>256

N/D

32

128

64

2

<0.5

R

N/D

-

-

-

-

-

HS13-312

wound

37

4

1

0.25

N/D

N/D

>256

N/D

32

64

16

4

4

R

N/D

-

-

-

-

-

HS13-313

urine

480

4

1

0.25

N/D

N/D

>256

N/D

64

128

64

2

<0.5

R

N/D

-

-

-

-

-

E. faecium

                   

HS11-306

urine

650

4

2

0.25

N/D

N/D

>256

N/D

32

128

16

4

2

S

N/D

-

-

-

-

-

  1. ST, sequence typing; R, resistant; S, susceptible; LZD, linezolid; VAN, vancomycin; OXA, oxacillin; FOX, cefoxitin; ERY, erythromycin; CLI, clindamycin; CHL, chloramphenicol; TET, tetracycline; CIP, ciprofloxacin; PEN, penicillin; AMP, ampicillin; GNH, high-level gentamicin; SXT, trimethoprim-sulfamethoxazole; N/D, not determined.
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BMC Microbiology

ISSN: 1471-2180

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